40Hz with Glymphatic system

The glymphatic system is a recently discovered waste clearance system in the central nervous system of vertebrates, acting as a "pseudo-lymphatic" system for the brain. It facilitates the removal of metabolic waste products and other substances from the brain's interstitial fluid, primarily during sleep. This system is crucial for maintaining brain health and its dysfunction is implicated in neurodegenerative diseases. https://www.nature.com/articles/s41586-024-07132-6 https://scrapbox.io/files/68513c3c17dabf4ce423d7e9.jpeg https://scrapbox.io/files/68524c67e21648d7aaea1267.jpeg A hydrophobic peptide accumulating in the brains of Alzheimer's patients. Measuring blood concentrations requires high sensitivity. Dementia patients in Japan are estimated at over 6 million, approximately 24 million worldwide, and projected to reach 80 million in 2040. A hydrophobic peptide accumulating in the brains of Alzheimer's patients. Measuring blood concentrations requires high sensitivity. Dementia patients in Japan are estimated at over 6 million, approximately 24 million worldwide, and projected to reach 80 million in 2040. Studies using mouse models showed that stimulation with 40Hz light or sound promotes clearance of amyloid-β from the brain. This stimulation is thought to activate the brain’s glymphatic system (its waste-disposal system) and promote amyloid-β clearance. 40Hz stimulation is also expected to reduce brain atrophy due to Alzheimer’s disease and prevent cellular damage.

The glymphatic system is a recently discovered waste clearance system in the central nervous system of vertebrates, acting as a "pseudo-lymphatic" system for the brain. It facilitates the removal of metabolic waste products and other substances from the brain's interstitial fluid, primarily during sleep. This system is crucial for maintaining brain health and its dysfunction is implicated in neurodegenerative diseases. https://www.nature.com/articles/s41586-024-07132-6 https://scrapbox.io/files/68513c3c17dabf4ce423d7e9.jpeg https://scrapbox.io/files/68524c67e21648d7aaea1267.jpeg アルツハイマー病患者の脳に蓄積する疎水性ペプチドである。 血中濃度の測定には高感度化が求められる。 本邦での認知症患者数は600万人以上と推定され、世界では約2,400万人、2040年には8,000万人にも達すると考えられている。 アルツハイマー病患者の脳に蓄積する疎水性ペプチドである。 血中濃度の測定には高感度化が求められる。 本邦での認知症患者数は600万人以上と推定され、世界では約2,400万人、2040年には8,000万人にも達すると考えられている。 マウスモデルでの研究では、40Hzの光や音の刺激が、脳内のアミロイドβの除去を促進することが示されました. この刺激は、脳のグリンパティック系（老廃物を排出するシステム）の活動を活発化させ、アミロイドβの排出を促すと考えられています. また、40Hzの刺激は、アルツハイマー病による脳の萎縮を軽減し、細胞の損傷を防ぐ効果も期待されています.